Neuroprotective DAMPs member prothymosin alpha has additional beneficial actions against cerebral ischemia-induced vascular damages

作者：Maeda Shiori; Sasaki Keita; Halder Sebok Kumar; Fujita Wakako; Ueda Hiroshi^*

来源：Journal of Pharmacological Sciences, 2016, 132(1): 100-104.

DOI：10.1016/j.jphs.2016.05.006

• Cerebral ischemia
• Prothymosin alpha
• Vascular and neuronal protection

Prothymosin alpha (ProT alpha) suppresses stress-induced necrosis of cultured cortical neurons. As neuroprotection alone could not explain the long-lasting protective actions against cerebral ischemia by ProT alpha, we further examined whether ProT alpha, in addition to neuroprotective effects, has other anti-ischemic activities. When recombinant mouse ProT alpha (rmProT alpha) at 0.3 mg/kg was intravenously (i.v.) given 2 h after the start of tMCAO, all mice survived for more than 14 days. In evaluation of CD31- and tomato lectin-labeling as well as IgG and Evans blue leakage, rmProTa treatment (0.1 mg/kg) largely blocked ischemia-induced vascular damages. Therefore, rmProT alpha has novel beneficial effects against ischemia-induced brain damage through vascular mechanisms.

• 出版日期2016-9