Are natural killer cells involved in multiple sclerosis etiology? Evidences from NKp46/NCR1 receptor modulation in an observational study

作者：Galuppo Maria; Giacoppo Sabrina; Sessa Edoardo; Bramanti Placido; Mazzon Emanuela^*

来源：Journal of the Neurological Sciences, 2014, 345(1-2): 248-251.

DOI：10.1016/j.jns.2014.07.045

• Natural killer cells
• Multiple sclerosis
• Interferon-beta
• Natalizumab
• NKp46/NCR1 receptor
• Peripheral blood mononuclear cells

Natural killer (NI() cells are implicated in many autoimmune diseases but their role in multiple sclerosis (MS) remains still unknown. This study was aimed to evaluate the expression levels of a NK cell receptor (NCR1) in patients with diagnosis of MS. Particularly, the study took into account patients undergoing pharmacological therapy with interferon-beta or natalizumab and patients never treated since first-time diagnosed for MS. Expression levels of NCR1 receptor were evaluated in protein extracts of peripheral blood mononuclear cells performing western blot analysis.
Our results show that MS patients display higher NCR1 expression levels than healthy controls. Moreover, patients with a first diagnosis of MS display the highest level of NCR1 when compared with patients pharmacologically treated with interferon-beta or natalizumab.
Therefore, pharmacologically treated MS patients show a modulated NK cell expression.

• 出版日期2014-10-15