A novel 3,4-dihydronaphthalen-1(2H)-one with spiro-butyrolactone and a new isocoumarin isolated from the endophytic fungus Phoma sp YN02-P-3

作者：Sang, Xia-Nan; Chen, Shao-Fei; An, Xiao; Chen, Gang; Wang, Hai-Feng^*; Pei, Yue-Hu^*

来源：Journal of Asian Natural Products Research, 2017, 19(5): 436-443.

DOI：10.1080/10286020.2016.1217521

• Naphthalene
• isocoumarin
• Phoma sp
• cytotoxic activity

A novel 3,4-dihydronaphthalen-1(2H)-one with spiro-butyrolactone phomol (1) and a new isocoumarin phomasatin (2), together with two known compounds (3-4) were isolated from the solid culture of the endophytic fungus Phoma sp. YN02-P-3. Their structures including the absolute configurations were characterized on the basis of extensive 1D, 2D NMR (HSQC, HMBC, NOESY), MS, and CD spectral data. Compound 1 showed selective cytotoxic activity against HL-60 cell line with the IC50 value of 29.05M.

• 出版日期2017
• 单位沈阳药科大学