No association of IL-10 promoter SNP -592 and -1082 and SIDS

作者：Courts Cornelius^*; Madea Burkhard

来源：Forensic Science International, 2011, 204(1-3): 179-181.

DOI：10.1016/j.forsciint.2010.06.001

• Sudden infant death syndrome (SIDS)
• Interleukin-10
• Cytokine
• SNP genotyping

Sudden infant death syndrome (SIDS) constitutes a considerable percentage of infant death of unknown etiology. The genetically controlled pathway of cytokine mediated response to inflammation is presumed to play a role in SIDS. The A allele of SNP -592 of the promoter region of the anti-inflammatory cytokine IL-10 has been suggested to be associated with SIDS. Herein we investigated whether we could confirm this finding by SNP genotyping a series of 123 cases of SIDS and 406 control cases. We did not find a correlation between the A allele or an A allele containing genotype of IL-10 promoter SNP -592 and SIDS which is in contrast to previous studies. Also, in concordance with previous work, no association of the A allele or A allele containing genotypes of IL-10 promoter SNP -1082 and SIDS was found.

• 出版日期2011-1-30