Alpha-synuclein accumulates in the brain of scrapie-affected sheep and goats

作者：Adjou K T^*; Allix S; Ouidja M O; Backer S; Couquet C; Cornuejols M J; Deslys J P; Brugere H; Brugere Picoux J; El Hachimi K H

来源：Journal of Comparative Pathology, 2007, 137(1): 78-81.

DOI：10.1016/j.jcpa.2007.03.007

• alpha-synuclein
• goat
• prion disease
• scrapie
• sheep

Immunohistochemical examination demonstrated widespread granular deposits of alpha-synuclein (alpha SN) in the brains of sheep and goats with natural scrapie, especially in the cornu ammonis and subiculum of the hippocampus this contrasted with the diffuse and non-granular immunolabelling seen in healthy controls. There was nonregular "co-localization" of PrPSc and alpha SN. The findings resembled those reported in Creutzfeldt-Jakob disease and in experimental prion disease in hamsters and mice. The results suggest that perturbation of alpha SN metabolism plays a role in human and animal prion diseases.

• 出版日期2007-7
• 单位中国地震局