Molecular Aspects of Exercise-induced Cardiac Remodeling

作者：Bernardo Bianca C; McMullen Julie R

来源：Cardiology Clinics, 2016, 34(4): 515-+.

DOI：10.1016/j.ccl.2016.06.002

• Exercise
• Cardiac remodeling
• Molecular mechanisms
• Cardiac myocyte
• Cardiac hypertrophy
• Drug targets

Exercise-induced cardiac remodeling is typically an adaptive response associated with cardiac myocyte hypertrophy and renewal, increased cardiac myocyte contractility, sarcomeric remodeling, cell survival, metabolic and mitochondria! adaptations, electrical remodeling, and angiogenesis. Initiating stimuli/triggers of cardiac remodeling include increased hemodynamic load, increased sympathetic activity, and the release of hormones and growth factors. Prolonged and strenuous exercise may lead to maladaptive exercise-induced cardiac remodeling including cardiac dysfunction and arrhythmia. In addition, this article describes novel therapeutic approaches for the treatment of heart failure that target mechanisms responsible for adaptive exercise-induced cardiac remodeling, which are being developed and tested in preclinical models.

• 出版日期2016-11