ANTIOXIDANT AND CYTOTOXIC ACTIVITIES OF PHYLLOPHORA PSEUDOCERANOIDES (GMELIN) NEW. ET TAYL

作者：Trifan Adriana^*; Sava Daciana; Bucur Laura Adriana; Mihai Cosmin Teodor; Aprotosoaie Ana Clara; Cioanca Oana; Hancianu Monica; Miron Anca

来源：Farmacia, 2016, 64(4): 502-506.

• Phyllophora pseudoceranoides
• antioxidant activity
• cytotoxicity
• HeLa cells

The aim of the present study was to characterize and assess the in vitro antioxidant and cytotoxic activities of various solvent extracts from red alga Phyllophora pseudoceranoides. Bioactive compounds were extracted using solvents of different polarities. Total phenolic, flavonoid and carotenoid contents were also determined. Algal extracts displayed moderate 2,2-diphenyl-1-picryl-hydrazyl hydrate (DPPH) scavenging activity, with values ranging from 12.99 +/- 0.23 to 46.00 +/- 0.13 % at a concentration of 1.99 mg/mL; all extracts showed good scavenging activity against 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation, with EC50 values ranging from 0.12 +/- 0.02 to 0.49 +/- 0.02 mg/mL. All investigated extracts exhibited strong cytotoxic activities against HeLa cells. The antioxidant and cytotoxic effects of P. pseudoceranoides extracts suggest their possible use in the development of nutraceuticals and functional foods.

• 出版日期2016-8