Endoneurial edema in sural nerve may indicate recent onset inflammatory neuropathy

作者：Ueceyler Nurcan; Necula Gina; Wagemann Esther; Toyka Klaus V; Sommer Claudia

来源：Muscle & Nerve, 2016, 53(5): 705-710.

DOI：10.1002/mus.24930

• diagnosis
• endoneurial edema
• histology
• inflammatory neuropathy
• noninflammatory neuropathy
• polyneuropathy
• sural nerve biopsy

Introduction: Sural nerve biopsy is an important means of establishing the diagnosis of inflammatory neuropathies. We investigated the diagnostic value of endoneurial edema. Methods: Diagnostic sural nerve biopsies from 42 patients with inflammatory and 28 patients with noninflammatory neuropathies were re-evaluated for the presence of endoneurial edema. Edema was assessed on hematoxylin-eosin stained paraffin and frozen sections and on azure II-methylene blue stained semithin sections. We determined the area of endoneurial edema on digitized images in relation to the entire endoneurial area of each fascicle. Results: Edema was more extensive in neuropathies with short disease duration (12 months) as compared to long duration (>12 months; P<0.01). Edema in inflammatory neuropathies of 12 months duration covered a larger area than in noninflammatory neuropathies (P<0.01), and the extent of edema correlated negatively with disease duration (P<0.05). Conclusions: Endoneurial edema may be a useful additional disease marker in inflammatory neuropathies of recent onset. Muscle Nerve53: 705-710, 2016

• 出版日期2016-5