Anticancer Potential of Thiazole Derivatives: A Retrospective Review

作者：Jain Shweta; Pattnaik Satyanarayan; Pathak Kamla; Kumar Sushant; Pathak Devender; Jain Surendra; Vaidya Ankur^*

来源：Mini Reviews in Medicinal Chemistry, 2018, 18(8): 640-655.

DOI：10.2174/1389557517666171123211321

• Anticancer
• biological activity
• HIV
• thiazole
• thiazole derivatives
• structure-activity relationship

This review brings forth the potential of thiazole derivatives for their anticancer activities. The emphasis is placed on the structural diversity of thiazole derivatives, responsible for their specific anticancer activity. Multiple classes of thiazole derivatives such as Schiff base, mono-, di-, tri-, and heterocyclic substituents that possess anticancer activity have been exemplified. Molecular modelling of compounds that predicts enhanced anticancer activity of the modified structures has also been elaborated in the review. Significant advancements in synthetic chemistry related to cytotoxicity can now better position the drug discovery team to undertake thiazoles as valuable leads. The beneficial thiazole derivatives possessing anticancer activity will reignite the interest of medicinal chemists in thiazole and their derivatives.

• 出版日期2018