Glycans as Regulatory Elements of the Insulin/IGF System: Impact in Cancer Progression

作者：de Freitas Junior Julio Cesar M; Andrade da Costa Jessica; Silva Mariana Costa; Pinho Salome S^*

来源：International Journal of Molecular Sciences, 2017, 18(9): 1921.

DOI：10.3390/ijms18091921

• insulin
• IGF system
• glycans
• cancer
• glycosylation

The insulin/insulin-like growth factor (IGF) system in mammals comprises a dynamic network of proteins that modulate several biological processes such as development, cell growth, metabolism, and aging. Dysregulation of the insulin/IGF system has major implications for several pathological conditions such as diabetes and cancer. Metabolic changes also culminate in aberrant glycosylation, which has been highlighted as a hallmark of cancer. Changes in glycosylation regulate every pathophysiological step of cancer progression including tumour cell-cell dissociation, cell migration, cell signaling and metastasis. This review discusses how the insulin/IGF system integrates with glycosylation alterations and impacts on cell behaviour, metabolism and drug resistance in cancer.

• 出版日期2017-9