Phytochemical Compositions and Antioxidant and Anti-Inflammatory Activities of Crude Extracts from Ficus pandurata H. (Moraceae)

作者：Lv, Huiqing; Zhang, Xiaoping; Chen, XueZhi; Xie, Zhijun; Hu, Changfeng; Wen, Chengping^*; Jiang, Kezhi

来源：Evidence-Based Complementary and Alternative Medicine, 2013, 2013: 215036.

DOI：10.1155/2013/215036

• TUMOR-NECROSIS-FACTOR
• URATE CRYSTALS
• FACTOR-ALPHA
• INFLAMMATION
• CAPACITY
• GOUT
• PHENOLICS

Background. Ficus pandurata H. (Moraceae) is widely used in traditional Chinese medicine as a healthy food condiment or a medicine for treatment of various diseases including inflammation. Objective. The purpose of the present study is to investigate the phytochemical compositions and antioxidant and anti-inflammatory activities of crude water (FPW) and ethanolic extracts (FPE) from Ficus pandurata H. Methods. Phytochemical compositions were identified by a high-performance liquid chromatography-electrospray ionization-mass spectrometry method (HPLC-ESI-MS). The antioxidant activities were evaluated by diphenylpicrylhydrazyl (DPPH) and hydroxyl radical assays, and the anti-inflammatory activities were evaluated by paw edema and levels of inflammatory mediator TNF-alpha and PGE2 in monosodium urate (MSU) crystal-induced rats. Results. Six compounds were identified by HPLC-MS method, and abundance of phenolics was found in FPE. The FPE showed concentration-dependent-significant scavenging of DPPH and hydroxyl radicals with IC50 values 118.4 and 192.9 mu g/mL, respectively. The FPE treatment significantly inhibited the paw edema and the production of TNF-alpha and PGE2 in MSU crystal-induced rats. Conclusion. The FPE exerted stronger antioxidant and anti-inflammatory activities which may be attributed to its high phenolic content.

• 出版日期2013
• 单位浙江工业大学; 杭州师范大学; 浙江中医药大学