ApoE Type 4 Allele Affects Cognitive Function of Aged Population in Tianjin City, China

作者：Sun, Shoudan; Fu, Jingming; Chen, Jun; Pang, Wei; Hu, Ruomei; Li, Haiqiang; Tan, Long; Jiang, Yugang^*

来源：American Journal of Alzheimer's Disease and Other Dementias, 2015, 30(5): 503-507.

DOI：10.1177/1533317514566114

• apolipoprotein E type 4 allele
• cognitive function
• elderly people
• MMSE
• basic cognitive aptitude tests

Apolipoprotein E type 4 allele (ApoE4) is known as a risk gene for the late-onset Alzheimer's disease, and the relationship between ApoE4 and cognitive function of the elderly people has drawn the attention of the scientists. In this study, we investigated the relationship between ApoE4 and the cognitive function of the old people. A total of 156 old people were investigated, of whom 31 were ApoE4 carriers. The ApoE4 primarily influenced the global cognitive function, perceptual speed, and work memory. The results indicate that ApoE4 has significant negative effect on the cognitive function of the elderly people who are 60 years and older.

• 出版日期2015-8
• 单位天津市天津医院; 山东中医药大学