Advanced diagnostic support in lipidology project: role for phenotypic and functional evaluation of lipoproteins in dyslipidemias

作者：Ardigo D; Bernini F; Borghi C; Calandra S; Cicero A F G; Favari E; Fellin R; Franzini L; Vigna G B; Zimetti F; Zavaroni I^*

来源：Clinical Lipidology, 2010, 5(3): 329-337.

DOI：10.2217/CLP.10.20

• dyslipidemia
• intima-media thickness
• lipoprotein
• reverse cholesterol transport
• small dense LDL

The term 'dyslipidemia' includes a wide family of lipoprotein metabolic defects often related to cardiovascular diseases. Despite the complexity of lipid disorders, current guidelines indicate LDL-C as the single most important therapeutic target; however, other lipido-proteic parameters, such as the concentration of lipoprotein subfractions (e.g., small-dense LDL) or their functional capacity (e.g., HDL reverse cholesterol transport), may display direct pro- or anti-atherogenic properties. Traditional lipid profiles may therefore be inadequate in representing dyslipidemia complexity and may prove to be ineffective in estimating the overall patient's risk in this context. We designed a research project attempting to provide a coherent framework integrating traditional lipid profiling and advanced diagnostics, to assess qualitative and functional lipoprotein features in relevant clinical conditions and to correlate them with preclinical atherosclerosis.

• 出版日期2010-6