Analysis of multiple factors involved in acute progressive cerebral infarction and extra- and intracranial arterial lesions

作者：Chen, Yuefu; Liu, Yajie; Luo, Chenghong; Lui, Weiheng; Su, Binru^*

来源：Experimental and Therapeutic Medicine, 2014, 7(6): 1495-1505.

DOI：10.3892/etm.2014.1624

• progressive cerebral infarction
• carotid atherosclerosis
• cerebral artery stenosis
• stroke in progression

In order to identify the potential factors involved in the development of acute progressive cerebral infarction (PCI), the association between potential risk factors and extra- and intracranial arterial lesions was investigated. A total of 608 patients underwent cerebral angiography to analyze the morphological characteristics between the PCI and NPCI groups. In addition, data from numerous cases of extra- and intracranial arterial lesions were collected and compared with the control groups, and the associations between the severity of arterial lesions and the potential influential factors were analyzed. In the blood vessels responsible for cerebral infarction, various degrees of atherosclerotic plaques and stenosis were observed. Age, high-density lipoprotein (HDL) levels, glycosylated hemoglobin and blood pressure affected the degrees of hardening, plaques and stenosis. Analysis of cerebral artery stenosis revealed that age, diabetes mellitus and plasma fibrinogen were risk factors for cerebral artery stenosis, while the HDL/low density lipoprotein ratio was a protective factor. Therefore, the results of the present study indicate that the lesions of blood vessels are a major pathological change in PCI and multiple factors are involved in the pathogenesis.

• 出版日期2014-6
• 单位南方医科大学