Aspergillosis of Biliary Tract After Liver Transplantation: A Case Report

作者：Chen Yuchong; Zhu Dingheng; Yuan Zhizhong; Yu Hongyu; He Jing; Chen Jianghan^*

来源：Mycopathologia, 2010, 170(2): 117-121.

DOI：10.1007/s11046-010-9300-y

• Aspergillosis
• Biliary tract
• Organ transplantation
• Leukocytopenia

We reported a case of aspergillosis presented as cholangitis in a patient after liver transplantation, even with prophylactic use of fluconazole. The patient had multiple predisposing factors, such as leukocytopenia, immunosuppressive drug therapy. He died 2 days after an exploratory laparotomy was carried out. The histopathologic finding of biopsy specimen from biliary tract was positive for Aspergillus. And the pathogen was identified as Aspergillus flavus by mycological culture and PCR. The patient was confirmed as a case of Aspergillosis of biliary tract that was responded poorly to fluconazole. This indicated that azole should have been switched to more effective antifungal agents at earlier stage when the patients responded poorly to the original treatment.

• 出版日期2010-8
• 单位天津市中医药研究院附属医院; 中国人民解放军第二军医大学