Dectin-1 Is Not Required for Controlling Candida albicans Colonization of the Gastrointestinal Tract

作者：Vautier Simon; Drummond Rebecca A; Redelinghuys Pierre; Murray Graeme I; MacCallum Donna M; Brown Gordon D^*

来源：Infection and Immunity, 2012, 80(12): 4216-4222.

DOI：10.1128/IAI.00559-12

Candida albicans is normally found as a commensal microbe, commonly colonizing the gastrointestinal tract in humans. However, this fungus can also cause mucosal and systemic infections once immune function is compromised. Dectin-1 is an innate pattern recognition receptor essential for the control of fungal infections in both mice and humans; however, its role in the control of C. albicans colonization of the gastrointestinal tract has not been defined. Here, we demonstrate that in mice dectin-1 is essential for the control of gastrointestinal invasion during systemic infection, with dectin-1 deficiency associating with impaired fungal clearance and dysregulated cytokine production. Surprisingly, however, following oral infection, dectin-1 was not required for the control of mucosal colonization of the gastrointestinal tract, in terms of either fungal burdens or cytokine response. Thus, in mice, dectin-1 is essential for controlling systemic infection with C. albicans but appears to be redundant for the control of gastrointestinal colonization.

• 出版日期2012-12
• 单位河北医科大学