Upregulation of epidermal growth factor receptor 4 in oral leukoplakia

作者：Kobayashi Hiroshi; Kumagai Kenichi; Gotoh Akito; Eguchi Takanori; Yamada Hiroyuki; Hamada Yoshiki^*; Suzuki Satsuki; Suzuki Ryuji

来源：International Journal of Oral Science, 2013, 5(1): 14-20.

DOI：10.1038/ijos.2013.10

• epidermal growth factor receptor
• immunohistochemistry
• oral leukoplakia
• quantitative real-time polymerase chain reaction

In the present study, we investigate the expression profile of the epidermal growth factor receptor family, which comprises EGFR/ErbB1, HER2/ErbB2, HER3/ErbB3 and HER4/ErbB4 in oral leukoplakia (LP). The expression of four epidermal growth factor receptor (EGFR) family genes and their ligands were measured in LP tissues from 14 patients and compared with levels in 10 patients with oral lichen planus (OLP) and normal oral mucosa (NOM) from 14 healthy donors by real-time polymerase chain reaction (PCR) and immunohistochemistry. Synchronous mRNA coexpression of ErbB1, ErbB2, ErbB3 and ErbB4 was detected in LP lesions. Out of the receptors, only ErbB4 mRNA and protein was more highly expressed in LP compared with NOM tissues. These were strongly expressed by epithelial keratinocytes in LP lesions, as shown by immunohistochemistry. Regarding the ligands, the mRNA of Neuregulin2 and 4 were more highly expressed in OLP compared with NOM tissues. Therefore, enhanced ErbB4 on the keratinocytes and synchronous modulation of EGFR family genes may contribute to the pathogenesis and carcinogenesis of LP. International Journal of Oral Science (2013) 5, 14-20; doi:10.1038/ijos.2013.10; published online 15 March 2013

• 出版日期2013-3