Deregulated systemic IL-10/IL-12 balance in advanced and poor prognosis paediatric soft tissue sarcomas

作者：Bien Ewa^*; Krawczyk Malgorzata; Izycka Swieszewska Ewa; Trzonkowski Piotr; Kazanowska Bernarda; Adamkiewicz Drozynska Elzbieta; Balcerska Anna

来源：Biomarkers, 2013, 18(3): 204-215.

DOI：10.3109/1354750X.2013.764351

• Children
• interleukin 10
• interleukin 12
• prognostic factors
• soft tissue sarcomas
• Th1/Th2 balance

Context: The roles of interleukin 10 (IL-10) and IL-12 in regulation of cancer growth and Th1/Th2 immune responses towards cancer are unclear.
Objective: To establish the prognostic significance of serum IL-10 and IL-12 in paediatric soft tissue sarcomas (STS).
Materials and methods: ELISA determinations of cytokines were performed as pre-treatment in 59 children with STS and 30 healthy controls.
Results: Elevated IL-10 and decreased IL-12 serum levels correlated with advanced disease, poor response to chemotherapy and poor outcome. IL-10 >= 9.5 pg/ml, IL-12 <= 65 pg/ml and lymph nodes involvement independently predicted poor overall survival (OS) in multivariate Cox analysis.
Conclusion: Serum IL-10/IL-12 balance determination may facilitate to assess risk groups and prognosis in childhood STS.

• 出版日期2013-5