Dual Role of COUP-TF-Interacting Protein 2 in Epidermal Homeostasis and Permeability Barrier Formation

作者：Golonzhka Olga; Liang Xiaobo; Messaddeq Nadia; Bornert Jean Marc; Campbell Adam L; Metzger Daniel; Chambon Pierre; Ganguli Indra Gitali; Leid Mark^*; Indra Arup K

来源：Journal of Investigative Dermatology, 2009, 129(6): 1459-1470.

DOI：10.1038/jid.2008.392

COUP-TF-interacting protein 2 (CTIP2; also known as Bcl11b) is a transcription factor that plays key roles in the development of the central nervous and immune systems. CTIP2 is also highly expressed in the developing epidermis, and at lower levels in the dermis and in adult skin. Analyses of mice harboring a germline deletion of CTIP2 revealed that the protein plays critical roles in skin during development, particularly in keratinocyte proliferation and late differentiation events, as well as in the development of the epidermal permeability barrier. At the core of all of these actions is a relatively large network of genes, described herein, that is regulated directly or indirectly by CTIP2. The analysis of conditionally null mice, in which expression of CTIP2 was ablated specifically in epidermal keratinocytes, suggests that CTIP2 functions in both cell and non-cell autonomous contexts to exert regulatory influence over multiple phases of skin development, including barrier establishment. Considered together, our results suggest that CTIP2 functions as a top-level regulator of skin morphogenesis. Journal of Investigative Dermatology (2009) 129, 1459-1470; doi:10.1038/jid.2008.392; published online 18 December 2008

• 出版日期2009-6