mTOR trains heightened macrophage responses

作者：Horng Tiffany^*

来源：Trends in Immunology, 2015, 36(1): 1-2.

DOI：10.1016/Lit.2014.11.004

The ability of a primary challenge to protect against secondary infection (e.g., during vaccination) independent of the adaptive immune system is mediated in part by macrophage 'training'. Two new studies show that macrophage training is associated with genome-wide epigenetic changes and is regulated by the mTOR pathway and metabolic reprogramming.

• 出版日期2015-1