A novel CHS/ALG bi-layer composite membrane with sustained antimicrobial efficacy used as wound dressing

作者：Dong, Yang; Liu, Hong Zhuo; Xu, Lu; Li, Gang; Ma, Zi Ning; Han, Fei; Yao, Hui Min; Sun, Yan Hui; Li, San Ming^*

来源：Chinese Chemical Letters, 2010, 21(8): 1011-1014.

DOI：10.1016/j.cclet.2010.04.010

• Chitosan
• Alginate
• Composite membrane
• Ciprofloxacin HCl
• Sustained release
• Antimicrobial efficacy

A membrane composed of an alginate (ALG) layer and a chitosan (CHS) layer with sustained antimicrobial efficacy was prepared. Ciprofloxacin HCl (CIP) was incorporated into the ALG layer. Morphological feature of the composite membrane was analyzed by scanning electron microscopy (SEM). Water uptake capacity, in vitro drug release, and in vitro antimicrobial activity were evaluated. The composite membrane exhibited perfect binding characteristic between the two layers. The water uptake capacity of all the membranes was above 800%. The CIP could release from the composite membranes for 48 h. The membrane could control the bacterial growth persistently. The results suggested that this CHS/ALG composite membrane incorporated with CIP had the potential for wound dressing application.

• 出版日期2010-8
• 单位中国刑事警察学院; 沈阳药科大学