A NOVEL MEDIUM SIZE LACTAM RING ANALOGES AS ANTIBACTERIAL AGENTS: SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING STUDIES

作者：Harita Putcha A N V^*; Kumar Putcha Seshi; Guduru Shiva Krishna Reddy; Ravula Parameshwar; Chandra J N Narendra Sharath

来源：EXCLI Journal, 2017, 16: 1090-1098.

DOI：10.17179/excli2017-193

• medium size ring
• synthesis
• coupling reaction
• lactam
• bacillus subtilis
• anti-bacterial
• docking

A novel series of medium size (S)-3-alkyl-3,4,6,7-tetrahydro-1H-benzo[e][1,4] diazonine-2,5-dione (6a-f) analogues were synthesized from (E)-3-(2-nitrophenyl) acrylicacid (2) reacting with various amino acid esters using Di-isopropyl Carbodiimide as a coupling agent. The final cyclization is carried out by using reagent 1-Ethyl-3(3-dimethylaminopropyl) Carbodiimide Hydrochloride. The synthesized compounds have been supported by Mass, H-1-NMR and C-13-NMR. Further antibacterial studies were conducted, where some molecules are noticed with potent activity, especially molecule 6d shown highest activity which was also supported by molecular docking studies. All final molecules were docked with enzyme peptide deformylase to determine the probable binding conformation.

• 出版日期2017