Use of fractional laser microablation and ultrasound to facilitate the delivery of gold nanoparticles into skin in vivo

作者：Terentyuk G S^*; Genina E A; Bashkatov A N; Ryzhova M V; Tsyganova N A; Chumakov D S; Khlebtsov B N; Sazonov A A; Dolotov L E; Tuchin V V; Khlebtsov N G; Inozemtseva O A

来源：Quantum Electronics, 2012, 42(6): 471-477.

DOI：10.1070/QE2012v042n06ABEH014882

• gold nanocages with silicon dioxide coating
• delivery of nanoparticles into skin
• fractional laser microablation
• optical coherence tomography

The delivery of gold nanoparticles (nanocages coated with a layer of silicon dioxide (40/20 nm)) dispersed in the solution (glycerol + polyethylene glycol-400, 1:1) into the skin tissue is studied experimentally in vivo. From the data of optical coherence tomography and histochemical analysis it follows that simple application of suspension of nanoparticles is not efficient enough for delivery of the particles into the skin as a result of passive diffusion. It is shown that fractional laser microablation of skin before the application of the suspension, followed by the topical treatment by ultrasound allows penetration through the epidermis layer and delivery of nanoparticles into dermis and hypodermis

• 出版日期2012