Accuracy of SNPs to predict risk of HLA alleles associated with drug-induced hypersensitivity events across racial groups

作者：He, Yijing^*; Hoskins, Janelle M.; Clark, Scott; Campbell, Nathan H.; Wagner, Kim; Motsinger-Reif, Alison A.; McLeod, Howard L.

来源：Pharmacogenomics, 2015, 16(8): 817-824.

DOI：10.2217/PGS.15.41

• drug-induced hypersensitivity
• HLA
• human leukocyte antigen
• pharmacogenetics
• pharmacogenomics
• risk mitigation

Aim: To evaluate the potential usefulness of selected SNPs to predict specific HLA alleles that are associated with drug-induced hypersensitivity reactions (HSR) in different ethnic groups. Methods & results: Five specific HLA alleles known to predict HSR were tagged by seven SNPs (rs1061235-HLA-A*31:01; rs2395029-HLA-B*57:01; rs3909184-HLA-B*15: 02; rs9469003-HLA-B*58:01; rs3117583-HLA-B*58:01; rs9270986-HLADQA1*01:02 and rs3129900-HLA-DQA1*01:02). DNA from 24 African-Americans, 56 Asian, 44 Caucasians and 36 Hispanics of known high resolution HLA-A, B and DQA1 status were genotyped for tagSNPs using TaqMan. Sensitivity and specificity were considered the primary end points and were 100% across the four populations for rs2395029-HLA-B*57:01. SNP prediction of HLA-A*31:01 had 100% sensitivity and 84% specificity. Conclusion: This study demonstrates the utility of SNP tagging as a 'real time' approach to predict or exclude the presence of specific HLA alleles of known importance to HSR across diverse ethnic groups.

• 出版日期2015
• 单位中南大学