Association of PDCD1 polymorphism to systemic lupus erythematosus and rheumatoid arthritis susceptibility

作者：do Canto Luisa Matos; Della Justina Farias Ticiana; Medeiros Mayara Delagnelo; Coelho Cintia Callegari; Rodrigues Sereia Aline Fernanda; Fernandes de Carlos Back Lia Kubelka; de Mello Filipe Martins; Zimmermann Adriana Fontes; Pereira Ivanio Alves; de Souza Iliada Rainha^*

来源：Revista Brasileira de Reumatologia, 2016, 56(6): 483-489.

DOI：10.1016/j.rbre.2015.07.008

• Rheumatoid arthritis
• Systemic lupus erythematosus
• Autoimmunity
• PDCD1 gene
• PD1.3 polymorphisma

Objective: This study aims to analyze the relationship of programmed cell death 1 (PDCD1) gene polymorphism (PD1.3G/A - rs11568821) with features of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in a Southern Brazilian population.
Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed in 95 SLE and 87 RA patients and 128 control group individuals from Santa Catarina, Southern Brazil. The Hardy Weinberg equilibrium (HWE) test, and odds ratio (OR) were analyzed, considering CI 95% and p <= 0.05.
Results: The PD1.3A allele frequencies were 0.095 (SLE), 0.115 (RA) and 0.078 (controls). The genotypes of the control group were in HWE, while those of SLE and RA patients were not. However, we found no association between PD1.3 polymorphism and the SLE or RA susceptibility, nor clinical or epidemiological data.
Conclusion: There was no significant association between PD1.3 polymorphism and SLE or RA susceptibility in this Southern Brazilian population.

• 出版日期2016-12