3,4-Dihydro-quinolin-2-one derivatives from extremophilic Streptomyces sp LGE21

作者：Mahmoud Manar M; Abdel Razek Ahmed S; Frese Marcel; Soliman Hesham S M; Sewald Norbert; Shaaban Mohamed^*

来源：Medicinal Chemistry Research, 2018, 27(7): 1834-1842.

DOI：10.1007/s00044-018-2195-8

• New dihydroquinolin-2-ones
• Extremophilic Streptomyces sp.
• Taxonomy
• Biological activity

Three new naturally-occurring 3,4-dihydroquinoline-2-one derivatives: 8-Hydroxy-3,4-dihydro-1H-quinolin-2-one (1), 3,4-dihydro-1H-quinolin-2-one (2) and 8-methoxy-3,4-dihydro-1H-quinolin-2-one (3), together with linoleic acid, glycerol monolinoleate and phenyl acetic acid were isolated from the Streptomyces sp. LGE21, derived from Lemna gibba. Structures of the new alkaloids (1-3) were determined by extensive 1D and 2D NMR, and MS measurements. In vitro cytotoxic studies of 1-3 and linoleic acid, in comparison with the original extract were assayed against liver cancer HEPG2 cell line and the human cervix carcinoma cell line (KB-3-1). The antimicrobial activity of the strain extract and compounds 1-3 were achieved as well. The new metabolites exhibited weak cytotoxic activities against cancer cell lines and growth inhibitory activity against a panel of tested bacterial strains.

• 出版日期2018-7