Delayed preattentional functioning in early psychosis patients with cannabis use

作者：Pesa Nicole^*; Hermens Daniel F; Battisti Robert A; Kaur Manreena; Hickie Ian B; Solowij Nadia

来源：Psychopharmacology, 2012, 222(3): 507-518.

DOI：10.1007/s00213-012-2676-2

• Cannabis
• Marijuana
• Mismatch negativity
• P3a
• Psychosis
• MMN

Cannabis use is prevalent among the early psychosis (EP) population. The event-related potentials, mismatch negativity (MMN) and P3a are reduced in EP. Cannabinoids have been shown to modulate N-methyl-D-aspartate receptors which are involved in MMN generation. %26lt;br%26gt;This study is the first to investigate the effects of cannabis use on MMN/P3a in EP. %26lt;br%26gt;EP was defined as a history of psychosis or psychotic symptoms with no progression to date to chronic schizophrenia. Twenty-two EP patients with cannabis use (EP + CANN), 22 non-cannabis-using EP patients (EP-CANN) and 21 healthy controls participated in this study. MMN/P3a was elicited using a two-tone, auditory paradigm with 8% duration deviants. %26lt;br%26gt;As expected, EP-CANN showed marked reductions in MMN/P3a amplitudes compared to controls. However, EP + CANN showed evidence of a different pattern of neurophysiological expression of MMN/P3a compared to non-using patients, most notably in terms of delayed frontal MMN/P3a latencies. %26lt;br%26gt;This study provides further evidence that MMN/P3a deficits are present during early psychosis and suggests that this biomarker may have utility in differentiating substance- from non-substance-related psychoses.

• 出版日期2012-8