科研之友
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摘要
Serum monomeric immunoglobulin A (IgA) has powerful immunomodulatory roles in its ability to suppress immune responses. Monomeric IgA acts through Fc alpha RI, which plays a significant role in vivo in maintaining the integrity of immune responses by an inhibitory immunoreceptor tyrosine-based activation motif-mediated process and powerful inhibitory cellular effector mechanisms elicited by the IgA system.
Triggering of Fc alpha RI-mediated inhibitory function by Fab anti-Fc alpha RI-mediated inhibitory function is able to inhibit several inflammatory and autoimmune diseases including asthma and glomerulonephritis.
The use of monomeric IgA as a therapeutic tool in human inflammatory diseases may offer much potential.
- 出版日期2010-5
