Antibacterial and leishmanicidal activity of Bolivian propolis

作者：Nina N; Lima B; Feresin G E; Gimenez A; Capusiri E Salamanca; Schmeda Hirschmann G^*

来源：Letters in Applied Microbiology, 2016, 62(3): 290-296.

DOI：10.1111/lam.12543

• antibacterial activity
• bacteria
• Bolivia
• disinfectant
• leishmanicidal activity
• phenolics
• propolis
• triterpenes

The antimicrobial activity of Bolivian propolis was assessed for the first time on a panel of bacteria and two endemic parasitic protozoa. Ten samples of Bolivian propolis and their main constituents were tested using the micro-broth dilution method against 11 bacterial pathogenic strains as well as against promastigotes of Leishmania amazonensis and L.braziliensis using the XTT-based colorimetric method. The methanolic extracts showed antibacterial effect ranging from inactive (MICs>1000gml(-1)) to low (MICs 250-1000gml(-1)), moderate (625-125gml(-1)) and high antibacterial activity (MIC 312gml(-1)), according to the collection place and chemical composition. The most active samples towards Leishmania species were from Cochabamba and Tarija, with IC50 values of 121 and 78, 80 and 109gml(-1) against L.amazonensis and Leishmania brasiliensis respectively. The results show that the best antibacterial and antiprotozoal effect was observed for some phenolic-rich propolis.

• 出版日期2016-3