Potential risk of mitomycin C at high concentrations on peripheral nerve structure

作者：Sui Tao; Zhang Jinhong; Du Shihao; Su Changhui; Que Jun; Cao Xiaojian^*

来源：Neural Regeneration Research, 2014, 9(8): 821-827.

DOI：10.4103/1673-5374.131598

• nerve regeneration
• peripheral nerve injury
• mitomycin C
• myelin sheath
• laminectomy
• electrophysiology
• nerve function
• NSFC grant
• neural regeneration

Although the local application of mitomycin C may prevent epidural adhesion after laminectomy, mitomycin C can induce neurotoxicity in optic and acoustic nerves at high concentrations. To determine the safe concentration range for mitomycin C, cotton pads soaked with mitomycin C at different concentrations (0.1, 0.3, 0.5, and 0.7 mg/mL) were immediately applied for 5 minutes to the operation area of rats that had undergone laminectomy at L-1. Rat sciatic nerves, instead of dorsal nerves, were used in this study. The results showed that mitomycin C at 0.1-0.5 mg/mL did not damage the structure and function of the sciatic nerve, while at 0.7 mg/mL, mitomycin C significantly reduced the thickness of the sciatic nerve myelin sheath compared with lower concentrations, though no functional change was found. These experimental findings indicate that the local application of mitomycin C at low concentrations is safe to prevent scar adhesion following laminectomy, but that mitomycin C at high concentrations (> 0.7 mg/mL) has potential safety risks to peripheral nerve structures.

• 出版日期2014-4
• 单位南京医科大学; 东南大学; 山东第一医科大学