An Improved Synthesis of Methyl Protodioscin. II. A Direct E-ring Opening by BF3-Et2O/Ac2O from Dioscin Ester

作者：Wang, Bo; Liu, Yang^*; Liu, Xin; Cheng, Mao-sheng

来源：Chemistry Letters, 2012, 41(9): 1015-1017.

DOI：10.1246/cl.2012.1015

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A direct E-ring opening of dioscin ester by BF3-Et2O/Ac2O was studied, and methyl protodioscin was synthesized from dioscin ester in three steps with a total yield of 44%. The details of the E-ring opening reaction was discussed, and a prominent stability of C16-OAc was obversed.

• 出版日期2012-9-5
• 单位沈阳药科大学