A 3D Printed Implantable Device for Voiding the Bladder Using Shape Memory Alloy (SMA) Actuators

作者:Hassani Faezeh Arab; Peh Wendy Yen Xian; Gammad Gil Gerald Lasam; Mogan Roshini Priya; Ng Tze Kiat; Kuo Tricia Li Chuen; Ng Lay Guat; Luu Percy; Yen Shih Cheng*; Lee Chengkuo*
来源:Advanced Science, 2017, 4(11): 1700143.
DOI:10.1002/advs.201700143

摘要

Underactive bladder or detrusor underactivity (DU) is defined as a reduction of contraction strength or duration of the bladder wall. Despite the serious healthcare implications of DU, there are limited solutions for affected individuals. A flexible 3D printed implantable device driven by shape memory alloys (SMA) actuators is presented here for the first time to physically contract the bladder to restore voluntary control of the bladder for individuals suffering from DU. This approach is used initially in benchtop experiments with a rubber balloon acting as a model for the rat bladder to verify its potential for voiding, and that the operating temperatures are safe for the eventual implantation of the device in a rat. The device is then implanted and tested on an anesthetized rat, and a voiding volume of more than 8% is successfully achieved for the SMA-based device without any surgical intervention or drug injection to relax the external sphincter.

  • 出版日期2017-11