A case of oncogenic osteomalacia with preoperative secondary hyperparathyroidism: Description of the biochemical response of FGF23 to octreotide therapy and surgery

作者：Elston Marianne S; Stewart Inge J; Clifton Bligh Roderick; Conaglen John V^*

来源：Bone, 2007, 40(1): 236-241.

DOI：10.1016/j.bone.2006.07.027

• oncogenic osteomalacia
• fibroblast growth factor-23
• octreotide
• hypophosphatemia
• secondary hyperparathyroidism

Oncogenic osteomalacia is a rare condition characterized by a low serum phosphate, reduced tubular reabsorption of phosphate and a low or inappropriately normal 1,25 dihydroxyvitamin D and is usually secondary to a phosphaturic mesenchymal tumor. Complete tumor resection results in resolution of all features. We report a patient with oncogenic osteomalacia and concurrent secondary hyperparathyroidism. Serum phosphate failed to normalize preoperatively with octreotide therapy, although this treatment did suppress serum FGF23. The postoperative course was distinguished by marked hyperphosphatemia that was associated with elevated serum 1,25 dihydroxyvitamin D concentrations.

• 出版日期2007-1
• 单位河北医科大学