The degradation behavior of nanoscale HA/PLGA and alpha-TCP/PLGA composites

作者：Ege Duygu^*; Cameron Ruth; Best Serena

来源：Bioinspired, Biomimetic and Nanobiomaterials, 2014, 3(2): 85-93.

DOI：10.1680/bbn.13.00027

• biodegradable
• biomaterial
• composites

The aim of this work was to prepare and analyze the degradation properties of pure PLGA, homogeneous a-tricalcium phosphate (alpha-TCP)/PLGA and hydroxyapatite (HA)/PLGA composites for potential bone replacement applications. alpha-TCP and HA powders were prepared in-house and 25 nominal wt% of calcium phosphate (CaP) powder was incorporated into commercially available PLGA pellets by twin screw extrusion. The degradation studies showed that pure PLGA had the fastest degradation rate followed by HA/PLGA and alpha-TCP/PLGA. Overall, it was found that alpha-TCP acted as a better buffering agent than HA, resulting in reduced acid group autocatalysis and hence a slower degradation rate.

• 出版日期2014