A robust and modular synthesis of ynamides

作者：Mansfield Steven J; Campbell Craig D; Jones Michael W; Anderson Edward A^*

来源：Chemical communications, 2015, 51(16): 3316-3319.

DOI：10.1039/c4cc07876d

A flexible, modular ynamide synthesis is reported that uses trichloroethene as an inexpensive two carbon synthon. A wide range of amides and electrophiles can be converted to the corresponding ynamides, importantly including acyclic carbamates, hindered amides, and aryl amides. This method thus overcomes many of the limitations of other approaches to this useful functionality.

• 出版日期2015