An enantioselective synthesis of the bicyclic core of the marine natural product awajanomycin

作者：Pritchard Deiniol R; Wilden Jonathan D^*

来源：Tetrahedron Letters, 2010, 51(14): 1819-1821.

DOI：10.1016/j.tetlet.2010.01.123

• Ring-closing metathesis
• delta-Lactam
• Acremonium sp.
• Diastereoselective hydroxylation

A concise stereoselective synthesis of the N-benzylated bicyclic core of the marine natural product awajanomycin is described starting with naturally Occurring L-alanine. Key steps in the synthesis include a ring-closing metathesis to establish a delta-lactam ring followed by a stereoselective hydroxylation to instal the quaternary centre.

• 出版日期2010-4-7