An NBD-NH2 fluorescent probe for bioimaging: existence of a specific detection of ClO-

作者：Yang, Yunxia; Zhang, Di; Xu, Mengsheng; Wang, Jianhong; Chen, Jipeng; Wang, Le^*

来源：Monatshefte fur Chemie, 2018, 149(6): 1003-1008.

DOI：10.1007/s00706-018-2143-9

• NBD-NH2
• Fluorescent probe
• Hypochlorous

A fluorescent probe 4-amino-7-nitrobenz-2-oxa-1,3-diazole NBD-NH2 for critical sensing hypochlorous (ClO-) has been developed in this paper. Probe NBD-NH2 exhibited excellent sensitivity and high selectivity toward detection of ClO- in CH3CH2OH/HEPES solution (1:4, v/v, 10 mM, pH 7.4), where the detection limit as low as 40 nM. The green fluorescence of NBD-NH2 was distinctly quenched by addition of ClO-. In addition, the new probe was also applied for bioimaging using HeLa cells and exist a critical detection of ClO- in living cells.
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• 出版日期2018-6
• 单位上海工程技术大学; 河南省农业科学院