An easy route to synthetic analogues of radicamine B, codonopsine and codonopsinine from D-mannitol

作者:Dharuman Suresh; Palanivel Ashok Kumar; Vankar Yashwant D*
来源:Organic and Biomolecular Chemistry, 2014, 12(27): 4983-4998.
DOI:10.1039/c4ob00503a

摘要

A general strategy for the synthesis of analogues of radicamine B has been carried out from D-mannitol. This method has been further extended to the synthesis of analogues of codonopsine and codonopsinine using appropriate Grignard reagents. The hence obtained molecules have been tested against various commercially available glycosidases and found to act as moderate to good inhibitors.

  • 出版日期2014