A First Report on Hb Q-Iran in Association with Alpha-thalassemia in a Case of Spinal Ischemia

作者：Zur Berndt^*; Hildesheim Andreas; Ludwig Michael; Stoffel Wagner Birgit

来源：Clinical Laboratory, 2011, 57(3-4): 221-224.

• Hb Q-Iran
• alpha-thalassemia
• vaso occlusion
• spinal ischemia

Background: Hemoglobin Q-Iran is a rare variant which has not been described in association with alpha-thalassemia to date. We present the case of a Turkish patient who developed spinal ischemia.
Methods: Spinal ischemia was diagnosed clinically, via magnetic resonance imaging and angiographically. Blood samples were analyzed by high performance liquid chromatography, electrophoresis, gene sequencing, hematological and biochemical analysis.
Results: We detected hemoglobin Q-Iran in association with alpha-thalassemia. The same hemoglobinopathy was detected in two members of the patient's family.
Conclusions: As various differential diagnosis approaches failed to reveal the cause of spinal ischemia, the combined hemoglobinopathy was eventually postulated. (Clin. Lab. 2011;57:221-224)

• 出版日期2011