Emergence of 2009A/H1N1 cases in a tertiary care hospital in New Delhi, India

作者：Broor Shobha^*; Gupta Swati; Mohapatra Sarita; Kaushik Samander; Mir Muneer A; Jain Priti; Dar Lalit; Lal Renu B

来源：Influenza and Other Respiratory Viruses, 2011, 5(6): R552-R557.

DOI：10.1111/j.1750-2659.2011.00274.x

• Emergence
• India
• New Delhi
• pandemic H1N1

Objective To determine virologic and epidemiologic characteristics of pandemic (H1N1) 2009 at All India Institute of Medical Sciences (AIIMS) a tertiary care hospital in New Delhi, India.
Methods Nasal and throat swabs from patients with febrile acute respiratory illness (FARI) from August to December 2009 (n = 1401) were tested for 2009A/H1N1 and seasonal influenza A viruses by real-time RT-PCR.
Results Of 1401 samples tested, 475 (33.9%) were positive for influenza A, of these majority (412; 87%) were 2009A/H1N1, whereas the remaining 63 (13%) were seasonal influenza A (49 were A/H3 and 14 were A/H1). While co-circulation of 2009A/H1N1 and A/H3 was observed in August-September, subsequent months had exclusive pandemic influenza activity (October-December 2009). Pandemic 2009A/H1N1 emergence did not follow typical seasonal influenza seasonality in New Delhi, which normally peaks in July-August, but instead showed bimodal peaks in weeks 39 and 48 in 2009. The percent of specimens testing positive for 2009A/H1N1 influenza virus was found to be highest in >5- to 18-year age group (41.2%; OR = 2.3; CI = 1.6-3.2; P = 0 00).
Conclusions Taken together, our data provide high prevalence of pandemic 2009A/H1N1 in urban New Delhi with bimodal peaks in weeks 39 and 48 and highest risk group being the children of school-going age (aged >5-18).

• 出版日期2011-11
• 单位河北医科大学