mu-NET: A Network for Molecular Biology Applications in Microfluidic Chips

作者：Donvito Lidia^*; Galluccio Laura; Lombardo Alfio; Morabito Giacomo

来源：IEEE/ACM Transactions on Networking, 2016, 24(4): 2525-2538.

DOI：10.1109/TNET.2015.2472564

• Biological information theory
• local area networks
• hydrodynamics
• medium access control
• switching

This paper introduces mu-NET, a microfluidic LAN that supports the exchange of both digital information and biochemical information carried by droplets moving across molecular processors in a microfluidic chip. The mu-NET can be used to support molecular biology applications like DNA, RNA, and protein biosynthesis. The mu-NET is the first realization of a microfluidic networking paradigm that controls movements of droplets in microfluidic chips by exploiting hydrodynamic phenomena only and builds on recent solutions to achieve communications in the microfluidic domain. The mu-NET integrates techniques to represent addressing information, as well as switching and medium access control solutions. In fact, in mu-NET, the address of the molecular processor where a droplet should be sent to is encoded into the distance between droplets; switching is executed to steer the droplets inside the microfluidic device; medium access control is applied to avoid collisions between droplets that may result in their fusion and, thus, loss of the biochemical information. In this paper, the design of mu-NET is presented in detail, and simulation results validating mu-NET operations are shown.

• 出版日期2016-8