ASYMMETRIC LEWIS ACID CATALYSIS OF ALUMINUM(SALALEN) COMPLEXES: FRIEDEL-CRAFTS REACTION OF INDOLE

作者：Suyama Keitaro; Matsumoto Kazuhiro; Katsuki Tsutomu^*

来源：Heterocycles, 2009, 77(2): 817-824.

DOI：10.3987/COM-08-S(F)93

• Asymmetric Reaction
• Friedel-Crafts Reaction
• Aluminum
• Indole
• Oxazolidinone

We examined the Lewis acid catalysis of chiral Al(salalen)X complexes and found that complex 1b (X = Br) serves as an efficient catalyst for the Friedel-Crafts reaction of indole with N-[(E)-alkenoyl]oxazolidin-2-ones. High enantioselectivity (up to 98% ee) was obtained under the optimized conditions.

• 出版日期2009-2-1