Analysis of Vis-NIR spectra changes to measure the inflammatory response in the nasal mucosal region of influenza A and B virus-infected patients

作者：Sakudo Akikazu^*; Baba Koichi; Ikuta Kazuyoshi

来源：Journal of Clinical Virology, 2012, 55(4): 334-338.

DOI：10.1016/j.jcv.2012.08.015

• Influenza A virus
• Influenza B virus
• Respiratory diseases
• Respiratory infection
• Vis-NIR spectra

Background: Human influenza A and B viruses cause severe seasonal respiratory tract infections, especially in infants and young children. Influenza A and B viruses have been reported to produce different symptoms and/or severity in infected patients, although these remain inconclusive. %26lt;br%26gt;Objectives and study design: In this study, non-invasive visible and near-infrared (Vis-NIR) spectroscopy was used for comparative analysis of the inflammatory response to influenza A and B virus infections, by measuring changes in water peak (970 nm) spectra collected from patient nasal mucosal regions. %26lt;br%26gt;Results: The results suggested that infection with influenza B virus induced more severe inflammatory responses in the nasal mucosal region than influenza A virus. %26lt;br%26gt;Conclusions: These are the first data showing different inflammatory responses to influenza A and B viruses at the sites of virus infection.

• 出版日期2012-12