Agglomeration Control of 1,4-Diazabicyclo (2.2.2)Octane Crystals by Operating Variables in Cooling Crystallization

作者：Duan Erhong^*; Du Zhao; Song Yu; Yang Kun; Liu Libin; Zhang Peng

来源：Molecular Crystals and Liquid Crystals, 2013, 582(1): 129-135.

DOI：10.1080/15421406.2013.803925

• Agglomeration control
• cooling crystallization
• 1
• 4-diazabicyclo(2
• 2
• 2) octane crystals
• operating variables

The agglomeration of crystallized 1,4-diazabicyclo(2.2.2)octane was investigated in a turbulent agitated semibatch reactor. To modify the agglomeration of 1,4-diazabicyclo(2.2.2)octane, the crystallization operating factors, including the stirring rate, cooling rate, feed concentration, and aging, were studied. The mean particle size of the 1,4-diazabicyclo(2.2.2)octane in the product suspension increased with decreasing feed concentration and cooling rate. The products were characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD). The product obtained at the condition of crystalline concentration of 1.80g/mL, stirring rate of 200rpm, and cooling rate of 0.3K/min is hard to agglomerate.

• 出版日期2013-10-1
• 单位河北科技大学