Analysis of reaction products of astaxanthin and its acetate with reactive oxygen species using LC/PDA ESI-MS and ESR spectrometry

作者：Nishino Azusa; Maoka Takashi^*; Yasui Hiroyuki

来源：Tetrahedron Letters, 2016, 57(18): 1967-1970.

DOI：10.1016/j.tetlet.2016.03.078

• Astaxanthin
• Reactive oxygen species
• Astaxanthin-endoperoxide
• Astaxanthin-epoxide
• Astaxanthin peroxide radical

Reaction products of astaxanthin and its acetate with hydroxy radical, superoxide anion radical, and singlet oxygen were analyzed by LC/PDA ESI-MS and ESR spectrometry. Astaxanthin epoxides were found to be major reaction products of astaxanthin with superoxide anion radical and hydroxyl radical. On the other hand, astaxanthin endoperoxides were identified as major reaction products of astaxanthin with singlet oxygen. The same results were obtained in the case of astaxanthin acetate. The ESR study revealed that astaxanthin and its acetate take up superoxide anion radical by the formation of their epoxide through peroxide and oxide radicals.

• 出版日期2016-5-4