Analytic Comparison Between X-Ray Fluorescence CT and K-Edge CT

作者：Feng Peng; Cong Wenxiang; Wei Biao; Wang Ge^*

来源：IEEE Transactions on Biomedical Engineering, 2014, 61(3): 975-985.

DOI：10.1109/TBME.2013.2294677

• Gold nanoparticles (GNPs)
• image noise
• image resolution
• K-edge computed tomography (CT)
• signal-to-noise ratio (SNR)
• X-ray fluorescence computed tomography (XFCT)

X-ray fluorescence computed tomography (XFCT) and K-edge computed tomography (CT) are two important modalities to quantify a distribution of gold nanoparticles (GNPs) in a small animal for preclinical studies. It is valuable to determine which modality is more efficient for a given application. In this paper, we report a theoretical analysis in terms of signal-to-noise ratio (SNR) for the two modalities, showing that there is a threshold of GNPs concentration such that XFCT has a better SNR than K-edge CT when GNPs concentration is less than this threshold, vice versa. Numerical tests are performed for XFCT and K-edge CT on two kinds of phantoms with multiple concentration levels and structural features. Experimental results illustrate that XFCT is superior to K-edge CT when contrast concentration is lower than 0.4% which coincides with the theoretical analysis.

• 出版日期2014-3
• 单位重庆大学