Up-regulation of long non-coding RNA CCAT2 correlates with tumor metastasis and poor prognosis in cervical squamous cell cancer patients

作者：Chen, Xin; Liu, Lifen; Zhu, Weipei^*

来源：International Journal of Clinical and Experimental Pathology, 2015, 8(10): 13261-13266.

• Cervical squamous cell cancer
• IncRNA CCAT2
• overall survival
• progression-free survival

Background: Dysregulation of long non-coding RNAs (IncRNAs) plays critical roles in tumor progression. The purpose of this study was to investigate the relationship between IncRNA CCAT2 expression and cervical squamous cell cancer susceptibility and prognosis. Methods: Expression levels of IncRNA CCAT2 in 123 cervical squamous cell tumor specimens were determined by quantitative real-time PCR (qRT-PCR), to clarify the clinical significance of IncRNA CCAT2 in cervical squamous cell cancer, we further discussed the relationship between IncRNA CCAT2 expression and overall survival (OS) and progression-free survival (PFS). Results: In the present study, we found that IncRNA CCAT2 was up-regulated in cervical squamous cell cancer tissues compared to the adjacent non-tumor tissues. In addition, the high IncRNA CCAT2 expression was significantly associated with the FIGO stage, lymph node metastasis and depth of cervical invasion (P<0.05). Furthermore, patients with high expression of IncRNA CCAT2 had poor OS (HR=2.813, 95% CI: 1.504-6.172; P=0.017), and PFS rates (HR=3.072, 95% CI: 1.716-8.174; P=0.008). Multivariate Cox proportional hazard model analysis demonstrated that high IncRNA CCAT2 expression was an independent poor prognostic factor for cervical squamous cell cancer patients. Conclusions: Our study suggested that high expression of IncRNA CCAT2 is related to the prognosis of cervical squamous cell cancer; it may be a new prognostic biomarker and potential therapeutic target for cervical squamous cell cancer intervention.

• 出版日期2015
• 单位苏州大学