Nitric oxide inhalation, a proposed strategy for early treatment of hemorrhagic shock

作者：Wang Ying; You Guoxing; Kan Xuemei; Chen Gan; Zhao Lian^*; Zhou Hong

来源：Medical Hypotheses, 2011, 77(2): 182-184.

DOI：10.1016/j.mehy.2011.04.005

Nitric oxide (NO), an endothelial-derived relaxing factor, plays important roles in a variety of pathophysiological conditions such as hemorrhagic shock (HS). So far, the impact of NO administration in HS treatment has been controversial. Through literature review, we summarize here the biphasic effects of NO in early and late phases of HS. Evidence suggests that NO administration is beneficial in the early stage while detrimental in the late stage of HS. We further propose inhalation of NO as a novel therapeutic strategy for the treatment of HS in the early stage.

• 出版日期2011-8
• 单位中国人民解放军军事医学科学院