Acute phase response in porcine reproductive and respiratory syndrome virus infection

作者：Gomez Laguna J^*; Salguero F J; Pallares F J; Fernandez de Marco M; Barranco I; Ceron J J; Martinez Subiela S; Van Reeth K; Carrasco L

来源：Comparative Immunology, Microbiology and Infectious Diseases, 2010, 33(6): E51-E58.

DOI：10.1016/j.cimid.2009.11.003

• Porcine reproductive and respiratory syndrome
• Pathogenesis
• Acute phase proteins
• Proinflammatory cytokines

This study was focused on the changes observed in the serum concentration of haptoglobin (Hp), C-reactive protein (CRP), serum amyloid A (SAA) and Pig-major acute protein (Pig-MAP), during experimental porcine reproductive and respiratory syndrome virus (PRRSV) infection and in their relationship with the expression of interleukin 1 beta (IL-1 beta), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha). Hp and Pig-MAP serum levels were increased at 10 dpi, but CRP and SAA showed a delayed and highly variable increase. All three proinflammatory cytokines were poorly expressed, and only a mild increase in IL-1b was observed at 7 dpi. The increased expression of Hp coincided with the light enhancement observed in both IL-6 and TNF-alpha, and might be related with an increased expression of IL-10. The low expression of TNF-alpha might point to a possible mechanism of viral evasion of host-immune response. This issue and the delayed expression of CRP and SAA should be taken into account in future studies about modulation of the immune response by PRRSV infection.

• 出版日期2010-12