Apelin polymorphism predicts blood pressure response to losartan in older Chinese women with essential hypertension

作者：Jia J; Men C; Tang K T; Zhan Y Y^*

来源：Genetics and Molecular Research, 2015, 14(2): 6561-6568.

DOI：10.4238/2015.June.12.10

• Apelin
• Polymorphism
• Losartan
• Hpertension
• Chinese

We determined whether the blood pressure response to losartan in an older Chinese population with essential hypertension was associated with apelin gene polymorphisms. We genotyped the -1860T>C polymorphism of the apelin gene in a case-control study of 222 patients with hypertension and 250 controls. Following 24 weeks of treatment with losartan (50 mg/day), reductions in systolic blood pressure were significantly different among the additive (CT vs CC vs TT), dominant (TT vs CC/CT), and recessive models (CC vs CT/TT; all P < 0.05) in women but not in men. In the additive model, the TT group showed the greatest reductions in systolic BP (23 +/- 10 mmHg) after treatment. The CT group showed greater reductions in systolic BP (21 +/- 11 mmHg) compared to the CC group (8 +/- 3 mmHg) (P < 0.05). The reductions in systolic BP of the TT and CT/CC groups were 23 +/- 10 and 19 +/- 10 mmHg, respectively. The reductions in systolic BP of the CC and TT/CT groups were 8 +/- 3 and 21 +/- 10 mmHg, respectively. After adjustment for confounding factors, quantitative trait analysis with a general linear model showed that the female patients with TT genotype showed greater reductions in systolic blood pressure after 24 weeks of treatment compared to the patients with the C allele (P < 0.05). The apelin -1860T>C genotype may play an important predictive role in the response to losartan in hypertensive women.

• 出版日期2015
• 单位南京医科大学